Restrictive cardiomyopathy
MONDO:0005201A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium.
Also known as: restrictive cardiomyopathy, familial restrictive cardiomyopathy
336 clinical trials for this condition and its sub-types, 18 tagged with Restrictive cardiomyopathy itself.
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Sub-types of Restrictive cardiomyopathy
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Non-familial restrictive cardiomyopathy 0 trials · 252 incl. sub-types
7 sub-types
- AL amyloidosis 93 trials · 99 incl. sub-types Sub-types →
- Wild type ATTR amyloidosis 95 trials
- Hypereosinophilic syndrome 19 trials · 49 incl. sub-types Sub-types →
- Cardiac sarcoidosis 19 trials
- AA amyloidosis 2 trials
- Loeffler endocarditis 0 trials
- Tropical endomyocardial fibrosis 0 trials
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Familial restrictive cardiomyopathy 0 trials · 62 incl. sub-types
10 sub-types
- Glycogen storage disease II 31 trials · 41 incl. sub-types Sub-types →
- Gaucher disease type I 12 trials
- ATTRV122I amyloidosis 7 trials
- Atrial standstill 1 trial Sub-types →
- Idiopathic hypereosinophilic syndrome 1 trial Sub-types →
- Cardiomyopathy, familial restrictive, 1 0 trials
- Cardiomyopathy, familial restrictive, 2 0 trials
- Cardiomyopathy, familial restrictive, 3 0 trials
- Cardiomyopathy, familial restrictive, 6 0 trials
- Dilated cardiomyopathy 1KK 0 trials
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Endomyocardial fibrosis 16 trials
Most studied deeper sub-types
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Heart scans may soon replace Needle-Based catheter tests
Diagnosis CompletedThis study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…
Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Diagnosis
Last updated Jul 18, 2026 00:00 UTC
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Could a diabetes drug ease heart failure in rare amyloid disease?
Symptom relief CompletedThis study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…
Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Heart conditions in kids: study reveals impact on daily life and play
Knowledge-focused CompletedThis study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…
Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Heart condition costs under the microscope in massive hospital study
Knowledge-focused CompletedThis study collected information from over 15,000 people hospitalized with cardiomyopathy, a heart muscle disease. Researchers looked at how much these hospital stays cost and what the money was spent on. The goal was to understand the real-world financial impact and help manage …
Sponsor: China National Center for Cardiovascular Diseases • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC
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Could your lifetime workout routine protect your heart?
Knowledge-focused CompletedThis study looked at whether being physically active over a lifetime is linked to developing a rare heart disease called wild-type transthyretin amyloid cardiomyopathy. Researchers compared the exercise histories of 180 people over age 60, including those with the disease, those …
Sponsor: Medical University of Graz • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Protein clues could spot rare disease years early
Knowledge-focused CompletedThis study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Menopause may stiffen the hearts of female endurance athletes
Knowledge-focused CompletedThis study looked at whether menopause makes the heart stiffer and reduces exercise ability in female endurance athletes. Researchers compared postmenopausal female athletes to premenopausal females and older male athletes using heart scans and exercise tests. The goal is to unde…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC