Renal tubular acidosis

MONDO:0001909

A group of genetic disorders of the kidney tubules characterized by the accumulation of metabolically produced acids with elevated plasma chloride, hyperchloremic metabolic acidosis. Defective renal acidification of urine (proximal tubules) or low renal acid excretion (distal tubules) can lead to complications such as hypokalemia, hypercalcinuria with nephrolithiasis and nephrocalcinosis, and rickets.

2 clinical trials for this condition and its sub-types, 2 tagged with Renal tubular acidosis itself.

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Where it sits in the disease tree

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Part of

↑ Renal tubule disorder (47) ↑ Acidosis disorder (23) ↑ Renal tubular transport disease (17)

Sub-types of Renal tubular acidosis

Hyperkalemic renal tubular acidosis 0 trials
Neuroaxonal dystrophy renal tubular acidosis 0 trials
Proximal renal tubular acidosis 0 trials
2 sub-types
- Autosomal dominant proximal renal tubular acidosis 0 trials
- Autosomal recessive proximal renal tubular acidosis 0 trials
Renal tubular acidosis 3 0 trials
Renal tubular acidosis, distal, 3, with or without sensorineural hearing loss 0 trials

Including sub-types (2) Tagged with Renal tubular acidosis (2)

Not yet finished but already full! 1 Terminated 1

New drug aims to keep acid in check for rare kidney disorder

Disease control Stopped early

This study tested a medicine called ADV7103 in children and adults with distal renal tubular acidosis (dRTA), a rare kidney condition that causes too much acid in the blood. The goal was to see if ADV7103 could prevent dangerous acid buildup better than a placebo. Only 3 people e…

Phase 3 • Sponsor: Advicenne Pharma • Aim: Disease control

Last updated Jun 27, 2026 13:01 UTC

Renal tubular acidosis

Where it sits in the disease tree

New drug aims to keep acid in check for rare kidney disorder