Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions
MONDO:0006397A group of kidney carcinomas characterized by the presence of different translocations involving the chromosome Xp11.2. These translocations result in the creation of gene fusions involving the TFE3 gene. Patients are usually children and young adults. Morphologically, the malignant epithelial cells form papillary patterns.
Also known as: TFE3-Rearranged renal cell carcinoma, Xp11.2 translocation-related renal cell carcinoma, renal cell cancer associated with Xp11.2 translocations/TFE3 Gene fusions, renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions, tRCC, translocation-associated renal cell carcinoma
2783 clinical trials for this condition and its sub-types, 7 tagged with Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions itself.
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New registry aims to unlock secrets of rare kidney cancer
Knowledge-focused CompletedThis completed study created a registry of 28 patients with TFE renal cell carcinoma, a rare kidney cancer. Researchers collected medical data, tumor samples, and images to better understand the disease. The goal is to use this information to guide future research and develop mor…
Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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8,000 kidney tumor samples collected to unlock cancer clues
Knowledge-focused CompletedThis completed research study collected and stored tumor tissue, blood, and urine samples from 8,000 children and young adults with kidney tumors. The goal was to help scientists study DNA changes and find biomarkers that could improve understanding of these cancers. No treatment…
Sponsor: Children's Oncology Group • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC