Recurrent respiratory papillomatosis
MONDO:0018955Recurrent respiratory papillomatosis is a rare respiratory disease characterized by the development of exophytic papillomas, affecting the mucosa of the upper aero-digestive tract (with a strong predilection for the larynx), caused by an infection with human papilloma virus. Symptoms at presentation may include hoarseness, chronic cough, dyspnea, recurrent upper respiratory infections, pneumonia, dysphagia, stridor, and/or failure to thrive.
Also known as: RRP, recurrent respiratory papillomatosis, AORRP (type), JORRP (type), adult-onset recurrent respiratory papillomatosis (type), juvenile laryngeal papilloma, juvenile-onset recurrent respiratory papillomatosis (type), laryngeal papilloma, recurrent
1442 clinical trials for this condition and its sub-types, 8 tagged with Recurrent respiratory papillomatosis itself.
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Sub-types of Recurrent respiratory papillomatosis
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Laryngeal papillomatosis 1 trial
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Can a vaccine plus a Blood-Vessel blocker stop airway growths from coming back?
Disease control Not yet recruitingThis phase II trial tests whether combining bevacizumab, a drug that limits blood vessel growth, with PRGN-2012, a vaccine-based therapy, can help adults with recurrent respiratory papillomatosis (RRP) avoid needing more surgeries. RRP causes wart-like growths in the airway that …
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Booster shot may extend time between surgeries for RRP patients
Disease control Not yet recruitingThis study tests whether a one-time booster dose of the Gardasil-9 vaccine can lengthen the time between surgeries for adults with recurrent respiratory papillomatosis (RRP), a condition where non-cancerous growths keep coming back in the airway. Researchers will enroll 50 adults…
Phase 1/2 • Sponsor: Ohio State University • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC