Raynaud disease
MONDO:0008364An episodic vasoconstriction resulting in discoloration of the skin and pain in the affected areas, often involving fingers or toes. Classically associated with triphasic color changes (white, blue, red) but may be biphasic. Often occurs in response to cold temperatures or emotional stress. May be primary or secondary to an underlying autoimmune disease.
Also known as: Raynaud disease, Raynaud syndrome, Raynaud's disease, Raynaud's syndrome, Raynaud's syndrome (disorder) [ambiguous], secondary Raynaud disease, secondary Raynaud phenomenon, secondary Raynaud's disease
15 clinical trials for this condition and its sub-types, 10 tagged with Raynaud disease itself.
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New pill offers hope for fingers that turn white and blue in the cold
Symptom relief Recruiting nowThis study tests an oral pill called treprostinil in 30 adults with severe Raynaud's phenomenon that hasn't improved with usual therapies. Raynaud's causes fingers and toes to change color and become painful when cold or stressed. Participants will take the pill three times daily…
Phase 4 • Sponsor: Brigham and Women's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Could a Smartwatch-Like device ease scleroderma symptoms?
Symptom relief Recruiting nowThis study tests whether a wearable device called Apollo Neuro can reduce fatigue and Raynaud's attacks in people with systemic sclerosis (scleroderma). The device delivers gentle vibrations to the skin. 160 participants will wear it daily for 6 weeks and report their symptoms. T…
Sponsor: Robyn T. Domsic, MD, MPH • Aim: Symptom relief
Last updated Jun 27, 2026 08:09 UTC
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New registry aims to unlock secrets of nerve treatment for fainting disorders
Knowledge-focused Recruiting nowThis study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …
Sponsor: SABAMED Medical Center Ltd. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC