Pure autonomic failure
MONDO:0018608Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.
Also known as: Bradbury Eggleston syndrome, Bradbury-Eggleston syndrome, PAF, Pure dysautonomia, Pure idiopatic dysautonomia, idiopathic orthostatic hypotension, idiopathic orthostatic hypotension (a symptom), orthostatic hypotension (a symptom)
30 clinical trials for this condition and its sub-types, 18 tagged with Pure autonomic failure itself.
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Smart belt aims to stop fainting spells in nerve disorder patients
Symptom relief CompletedThis study tested an automated abdominal binder that inflates when a person stands, applying pressure to help maintain blood pressure. It included 28 adults with autonomic failure and disabling orthostatic hypotension. Participants wore either the active binder or a sham version …
Phase 1/2 • Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Scientists Fine-Tune diagnostic tools for autonomic nervous system disorders
Knowledge-focused CompletedThis study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Belly band or pill? study tests best way to treat dizzy spells in nerve disease
Knowledge-focused CompletedThis study looked at two common treatments for low blood pressure upon standing in people with autonomic failure: the drug midodrine and an abdominal compression belt. Researchers measured how each affects heart health markers like pulse wave velocity. The trial involved 31 adult…
Early phase 1 • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Could a simple belly wrap beat pills for dizziness when standing?
Knowledge-focused CompletedThis study looked at how an abdominal compression binder (like a tight belt) helps people with autonomic failure who get dizzy or faint when standing due to low blood pressure. Researchers compared the binder to a standard medication (midodrine) and a placebo in 21 adults. The go…
Phase 1 • Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Hunting for hidden clues: study seeks early warning signs of parkinson disease
Knowledge-focused CompletedThis study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, such as family history, loss of smell, blood pressure drops, or a sleep disorder. Participants underwent brain scans, spinal taps, and other tests over several y…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:15 UTC