Proximal spinal muscular atrophy

MONDO:0019079

Proximal spinal muscular atrophies are a group of neuromuscular disorders characterized by progressive muscle weakness resulting from the degeneration and loss of the lower motor neurons in the spinal cord and the brain stem nuclei.

Also known as: SMA, Spinal Muscular Atrophy

57 clinical trials for this condition and its sub-types, 14 tagged with Proximal spinal muscular atrophy itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary peripheral neuropathy (479) ↑ Spinal muscular atrophy (117)

Sub-types of Proximal spinal muscular atrophy

Spinal muscular atrophy, type 1 17 trials
Spinal muscular atrophy, type II 14 trials
Spinal muscular atrophy, type III 13 trials
Spinal muscular atrophy, type IV 2 trials
Autosomal dominant childhood-onset proximal spinal muscular atrophy 0 trials
3 sub-types
Lower motor neuron syndrome with late-adult onset 0 trials

Including sub-types (57) Tagged with Proximal spinal muscular atrophy (14)

Trials to join now! 5 Not yet recruiting 1 Not yet finished but already full! 4 Completed 4

Hidden fracture risk in kids with SMA under spotlight

Knowledge-focused Not yet recruiting

This study looks at bone health in children with spinal muscular atrophy (SMA), a condition that causes muscle weakness. Researchers want to find out how common fractures are and whether newer SMA treatments affect bone strength. They will review medical records from about 550 ch…

Sponsor: Sheffield Children's NHS Foundation Trust • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:24 UTC

Proximal spinal muscular atrophy

Where it sits in the disease tree

Hidden fracture risk in kids with SMA under spotlight