Progressive external ophthalmoplegia
MONDO:0005181A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422)
Also known as: chronic progressive external ophthalmoplegia [ambiguous], progressive external ophthalmoplegia, chronic progressive external ophthalmoplegia
24 clinical trials for this condition and its sub-types, 4 tagged with Progressive external ophthalmoplegia itself.
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Sub-types of Progressive external ophthalmoplegia
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Kearns-Sayre syndrome 5 trials
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Progressive external ophthalmoplegia with mitochondrial DNA deletions 0 trials · 2 incl. sub-types
8 sub-types
- Autosomal dominant progressive external ophthalmoplegia 1 trial · 2 incl. sub-types Sub-types →
- Mitochondrial DNA deletion syndrome with progressive myopathy 0 trials
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 1 0 trials
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2 0 trials
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 0 trials
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 0 trials
- Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 5 0 trials
- Progressive external ophthalmoplegia with mitochondrial dna deletions, autosomal recessive 6 0 trials
Most studied deeper sub-types
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Can we map the course of a rare mitochondrial disease?
Knowledge-focused Recruiting nowThis global study follows people with POLG-related disorders, a group of rare mitochondrial conditions, to understand how the disease progresses over time. By observing clinical changes in up to 300 participants of all ages, researchers aim to identify key milestones that could s…
Sponsor: The POLG Foundation • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Worldwide data pool could pave the way for mitochondrial disease trials
Knowledge-focused Recruiting nowThis study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …
Sponsor: LMU Klinikum • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Scientists launch massive mitochondrial disease registry to unlock secrets of rare disorders
Knowledge-focused Recruiting nowThis study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC