Primary vitreoretinal large b-cell lymphoma

This phase II trial is testing a combination of three drugs—zanubrutinib, rituximab, and methotrexate—given through the vein and directly into the eye, for people newly diagnosed with primary intraocular lymphoma, a rare cancer of the eye. The goal is to see if this regimen can i…

This study tests a new drug called epcoritamab, given with two other drugs (lenalidomide and rituximab), for people whose primary CNS lymphoma has returned or stopped responding to treatment. The goal is to see if this combination can shrink or control the cancer. About 60 adults…

This study tests an eye injection of ADX-2191 (a form of methotrexate) in 20 adults with primary vitreoretinal lymphoma, a rare eye cancer. The goal is to see if it safely clears cancer cells from the eye. Participants receive injections at different frequencies over 8 weeks.