Primary melanoma of the central nervous system
MONDO:0016747A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor.
Also known as: CNS melanoma, Central nervous system melanoma, central nervous system melanoma, central nervous system melanoma (disease), melanoma (disease) of central nervous system, melanoma of CNS, melanoma of central nervous system, melanoma of the CNS
2772 clinical trials for this condition and its sub-types, 2 tagged with Primary melanoma of the central nervous system itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Primary melanoma of the central nervous system
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Leptomeningeal melanoma 1 trial
2 sub-types
- Adult leptomeningeal melanoma 0 trials
- Pediatric leptomeningeal melanoma 0 trials
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Meningeal melanomatosis 0 trials
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Spinal cord melanoma 0 trials
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New hope for brain lining cancer: immunotherapy injected directly into spinal fluid
Disease control OngoingThis early-phase trial is testing whether the immunotherapy drug nivolumab can help people with melanoma or lung cancer that has spread to the leptomeninges (the lining of the brain and spinal cord). The drug is given both through a vein and directly into the spinal fluid via a l…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New cocktail of cancer drugs targets brain metastases in melanoma patients
Disease control OngoingThis Phase 2 trial tests whether combining bevacizumab (Avastin) with atezolizumab (Tecentriq), with or without cobimetinib (Cotellic), can shrink or control melanoma that has spread to the brain. The study enrolls 29 adults with untreated brain metastases who are not taking ster…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC