Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG
MONDO:0018977Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait.
Also known as: anti-MAG neuropathy, neuropathy associated with monoclonal IgM antibodies to myelin-associated glycoprotein
13 clinical trials for this condition and its sub-types, 8 tagged with Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG itself.
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Cancer drug could ease rare nerve disorder
Disease control Recruiting nowThis study tests whether zanubrutinib, a drug used for certain blood cancers, can improve nerve function in people with anti-MAG neuropathy—a rare condition causing numbness, weakness, and balance problems. About 50 adults in Italy will take the drug for 12 months. Researchers wi…
Phase 2 • Sponsor: Azienda Ospedaliera di Padova • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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New hope for rare nerve disease: rituximab trial targets good responders
Disease control Recruiting nowThis phase 3 trial tests whether the drug rituximab can improve disability in people with anti-MAG neuropathy, a rare nerve condition that causes progressive weakness and numbness. The study will enroll 90 participants who have had the disease for 5 years or less and have shown r…
Phase 3 • Sponsor: Centre Hospitalier Universitaire de Saint Etienne • Aim: Disease control
Last updated Jun 27, 2026 07:59 UTC
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New study aims to unravel nerve mysteries in rare diseases
Knowledge-focused Recruiting nowThis study looks at how nerves work in people with Charcot-Marie-Tooth disease and other nerve disorders like CIDP. Researchers will use special electrical tests and ultrasound to measure nerve and muscle changes. The goal is to better understand these conditions, not to test a n…
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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New study aims to unravel mysteries of rare nerve disorder
Knowledge-focused Recruiting nowThis study is gathering detailed information from 45 people with a rare nerve condition called IgM-anti-MAG peripheral neuropathy. The goal is to better understand the different types of the disease, how it changes over time, and how patients respond to treatments. Researchers wi…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC