Polymyalgia rheumatica
MONDO:0019735A syndrome characterized by pain, stiffness, and tenderness of the proximal muscle groups including the shoulder, pelvic girdle and the neck. There is no muscle atrophy and muscle biopsies do not reveal pathologic changes. Additional signs and symptoms include low grade fever, fatigue and depression.
Also known as: polymyalgia rheumatica, rhizomelic pseudopolyarthritis
30 clinical trials for this condition and its sub-types, 30 tagged with Polymyalgia rheumatica itself.
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New hope for PMR patients: Long-Term safety trial of secukinumab underway
Disease control OngoingThis study is testing the long-term safety of secukinumab, a biologic drug, in people with polymyalgia rheumatica (PMR). It includes 161 patients who already completed a 52-week study of secukinumab and had a relapse after stopping treatment. The main goal is to see how safe and …
Phase 3 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New drug could ease painful muscle condition and cut steroid use
Disease control OngoingThis phase 3 trial tests a biologic drug called olokizumab in 125 people with polymyalgia rheumatica, a condition causing muscle pain and stiffness. The drug is given as a shot every two weeks. The main goal is to see if it can control symptoms and allow patients to take lower do…
Phase 3 • Sponsor: R-Pharm International, LLC • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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Can a single drug free PMR patients from steroids?
Disease control OngoingThis phase 3 trial tests whether rituximab, a drug that calms certain immune cells, can help people with polymyalgia rheumatica (PMR) stop taking steroids without their symptoms returning. The study includes 174 adults who are currently experiencing a PMR relapse and cannot lower…
Phase 3 • Sponsor: Sint Maartenskliniek • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New taper strategy aims to free PMR patients from Long-Term steroids
Disease control OngoingThis study tests whether a nurse-led, step-by-step plan to slowly reduce prednisolone (a steroid) helps people with polymyalgia rheumatica stop the drug safely and stay in remission. About 120 newly diagnosed patients will either follow this structured taper or receive usual care…
Sponsor: Aarhus University Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New imaging methods could transform PMR diagnosis
Diagnosis OngoingThis study explores whether ultrasound and PET/CT scans can more accurately diagnose and monitor polymyalgia rheumatica (PMR), a condition causing muscle pain and inflammation. Researchers will follow 98 adults over 50 suspected of having PMR, using imaging at key points during t…
Sponsor: Kresten Krarup Keller • Aim: Diagnosis
Last updated Jun 27, 2026 07:51 UTC
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New tool could predict who will suffer from steroid side effects
Knowledge-focused OngoingThis study aims to create a tool that predicts which patients with inflammatory rheumatic diseases (like rheumatoid arthritis, vasculitis, or polymyalgia rheumatica) will develop serious side effects from long-term steroid use. Researchers will collect routine medical data—such a…
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC