Pneumocystosis
MONDO:0019121Human pneumocystosis is caused by an infectious agent, which (after recent nomenclature and taxonomy revisions) is now classed as the fungus Pneumocystis jiroveci. The prevalence is unknown. Pneumocystis jiroveci is an opportunistic infectious agent, developing in immunosuppressed patients. It is an air-borne infection, localized to the lungs. However, extrapulmonary involvement is seen in AIDS patients. The disease manifests progressively with coughing, respiratory problems (dyspnea) and fever, followed by acute respiratory insufficiency and death within a few weeks in untreated cases. The most reliable diagnostic method is bronchoalveolar lavage. The treatment of choice is cotrimoxazole.
Also known as: PCP, PJP, Pneumocystis, Pneumocystis Pneumonia, Pneumocystis carinii pneumonia, Pneumocystis jirovecii pneumonia, Pneumocystis pneumonia, pneumocystosis
69 clinical trials for this condition and its sub-types, 19 tagged with Pneumocystosis itself.
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Experimental drug TdCyd aims to reactivate Tumor-Fighting genes in advanced cancer
Disease control CompletedThis early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Could a mouthwash replace a tube down your throat to diagnose pneumonia?
Diagnosis CompletedThis study tests whether a simple salt-water mouth rinse can detect pneumocystis, a lung infection that can be life-threatening in people with weak immune systems. Current diagnosis requires coughing up sputum or a tube inserted into the lungs, which can be uncomfortable. Researc…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Diagnosis
Last updated Sep 18, 2026 00:00 UTC
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Could a simple mouth rinse replace invasive tests for a deadly pneumonia?
Diagnosis CompletedThis study tested whether a simple mouth rinse could help diagnose Pneumocystis pneumonia, a serious lung infection in people with weakened immune systems. Researchers used a PCR test on the rinse sample to look for the fungus, aiming to find a threshold that indicates active inf…
Sponsor: Rennes University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 14:00 UTC
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Blood test may speed up deadly fungal infection diagnosis
Diagnosis CompletedThis study looked at a blood test called Beta-D-glucan (BDG) to see how well it detects invasive fungal infections in people with weak immune systems. Researchers tested 280 patients and checked if two positive results within 15 days confirmed an infection. The goal is to help do…
Sponsor: Central Hospital, Nancy, France • Aim: Diagnosis
Last updated Jun 27, 2026 08:03 UTC
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New drug could shield transplant patients from deadly fungal infections
Prevention CompletedThis study tested a new medicine called rezafungin to see if it can prevent serious fungal infections in adults getting a bone marrow transplant. About 600 participants received either rezafungin or the standard treatment. The goal was to see if rezafungin helps more people stay …
Phase 3 • Sponsor: Mundipharma Research Limited • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC