Plexiform neurofibroma

MONDO:0003304

An elongated and multinodular neurofibroma, formed when the tumor involves either multiple trunks of a plexus or multiple fascicles of a large nerve, such as the sciatic. Some plexiform neurofibromas resemble a bag of worms, others produce a massive ropy enlargement of the nerve. (Adapted from WHO.)

Also known as: plexiform neurofibroma, plexiform neurofibroma (disease)

1478 clinical trials for this condition and its sub-types, 29 tagged with Plexiform neurofibroma itself.

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Where it sits in the disease tree

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Including sub-types (1478) Tagged with Plexiform neurofibroma (29)

Trials to join now! 13 Not yet finished but already full! 14 Completed 1 Terminated 1

Real-World study tracks Selumetinib's impact on NF1 tumors in children

Disease control Stopped early

This study observes children aged 3 to 18 with neurofibromatosis type 1 (NF1) who have symptomatic, inoperable plexiform neurofibromas and are starting treatment with selumetinib. Researchers will track how well the drug shrinks or stabilizes tumors, how long patients stay on tre…

Sponsor: AstraZeneca • Aim: Disease control

Last updated Jul 10, 2026 00:00 UTC

Plexiform neurofibroma

Where it sits in the disease tree

Real-World study tracks Selumetinib's impact on NF1 tumors in children