Pleuropulmonary blastoma

A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary blastoma is seen in children. Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there are other lesions or neoplasms that may affect patients or their families, including lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline mutations in DICER1 gene have been identified in families harboring pleuropulmonary blastomas.

Also known as: childhood pulmonary blastoma, paediatric pulmonary blastoma, pediatric pulmonary blastoma, pleuropulmonary blastoma, pleuropulmonary blastoma (morphologic abnormality), pulmonary blastoma of childhood, PPB, PPB familial tumor and dysplasia syndrome

2955 clinical trials for this condition and its sub-types, 4 tagged with Pleuropulmonary blastoma itself.