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Pleuropulmonary blastoma
MONDO:0011014A malignant neoplasm affecting the lungs and/or the pleura. Pleuropulmonary blastoma is seen in children. Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma. In approximately 25% of patients with pleuropulmonary blastoma, there are other lesions or neoplasms that may affect patients or their families, including lung or kidney cysts, and ovarian or testicular neoplasms. Heterozygous germline mutations in DICER1 gene have been identified in families harboring pleuropulmonary blastomas.
Also known as: childhood pulmonary blastoma, paediatric pulmonary blastoma, pediatric pulmonary blastoma, pleuropulmonary blastoma, pleuropulmonary blastoma (morphologic abnormality), pulmonary blastoma of childhood, PPB, PPB familial tumor and dysplasia syndrome
2966 clinical trials for this condition and its sub-types, 4 tagged with Pleuropulmonary blastoma itself.
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Sub-types of Pleuropulmonary blastoma
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Pleuropulmonary blastoma type 1 1 trial
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Pleuropulmonary blastoma type 2 1 trial
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Pleuropulmonary blastoma type 3 1 trial
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Fetal lung interstitial tumor 0 trials
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New hope for kids with rare lung cancer: tailored chemo trial launches
Disease control Recruiting nowThis phase 3 trial studies the best way to treat pleuropulmonary blastoma (PPB), a rare childhood lung tumor. For type I PPB, it compares surgery alone to surgery plus chemotherapy. For types II and III, it tests adding the drug topotecan to standard chemotherapy. About 110 child…
Phase 3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 27, 2026 00:00 UTC
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Rare cancer syndrome under the microscope: what families need to know
Knowledge-focused Recruiting nowThis study follows people with a rare genetic condition called DICER1 syndrome, which raises the risk of certain childhood cancers like pleuropulmonary blastoma. Researchers will collect medical histories, genetic samples, and tissue from up to 1,500 participants and their relati…
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Can a smartwatch track how kids recover from cancer surgery?
Knowledge-focused Recruiting nowThis study is testing whether smartwatches and blood tests can measure how well children recover after surgery to remove a solid tumor. About 40 children and their caregivers will wear smartwatches and answer questionnaires before surgery and for up to a year after. Researchers w…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC