Pleural mesothelioma
MONDO:0003308A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath.
Also known as: mesothelioma of pleura, mesothelioma of the pleura, pleura mesothelioma, pleural mesothelioma, pleural mesothelioma (disease), benign pleural mesothelioma, pleural mesothelioma (disease), benign
1517 clinical trials for this condition and its sub-types, 28 tagged with Pleural mesothelioma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Pleural mesothelioma
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Malignant pleural mesothelioma 71 trials · 75 incl. sub-types
2 sub-types
- Pleural epithelioid mesothelioma 8 trials
- Pleural sarcomatoid mesothelioma 2 trials
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Pleural adenomatoid tumor 0 trials
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Can a Chest-Injected drug drain Cancer's fluid trap?
Disease control CompletedThis trial tests an experimental drug, RSO-021, given directly into the chest cavity of people with malignant pleural effusion—a buildup of fluid around the lungs caused by advanced solid tumors or mesothelioma. The study aims to find a safe dose and check for early signs that th…
Phase 1/2 • Sponsor: RS Oncology LLC • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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Radiation and immunotherapy join forces against mesothelioma
Disease control CompletedThis early-phase trial is testing whether combining a precise type of radiation (SBRT) with immunotherapy can safely treat pleural mesothelioma, a rare cancer of the lung lining. About 20 adults with confirmed mesothelioma will receive both treatments. The main goal is to see if …
Phase 1 • Sponsor: Mayo Clinic • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Immunotherapy plus chemo shows promise in tough lung cancer
Disease control CompletedThis study tested whether adding the immunotherapy drug durvalumab to standard chemotherapy helps people with advanced pleural mesothelioma live longer. The trial included 214 adults whose cancer could not be removed by surgery. Participants received either the combination or a s…
Phase 3 • Sponsor: PrECOG, LLC. • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New hope for mesothelioma patients: experimental drug tested in 47-person trial
Disease control CompletedThis phase II trial tested a drug called Bintrafusp alfa (M7824) in 47 people with advanced pleural mesothelioma that had worsened after platinum-based chemotherapy. The drug aims to block two proteins that help tumors grow. Researchers measured how long patients lived without th…
Phase 2 • Sponsor: Fundación GECP • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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300 patients studied to uncover hidden causes of fluid in the lungs
Knowledge-focused CompletedThis completed study looked at 300 patients with pleural effusion—fluid buildup around the lungs—to find out what caused it. Researchers reviewed medical records to classify the fluid type and identify underlying conditions like heart failure, infection, or cancer. The goal was t…
Sponsor: Mansoura University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC