Pleomorphic xanthoastrocytoma
MONDO:0016690A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. It presents in the superficial cerebral hemispheres and involves the meninges. It typically affects children and young adults.
Also known as: PXA, pleomorphic Xantho-astrocytoma
1457 clinical trials for this condition and its sub-types, 7 tagged with Pleomorphic xanthoastrocytoma itself.
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New proton therapy aims to shield memory in kids with brain cancer
Disease control OngoingThis study tests a new way to give proton radiation to children with low-grade glioma, a common brain tumor. The goal is to avoid the hippocampus, a brain area key for memory, to reduce long-term memory loss. About 74 children will receive this targeted radiation, and researchers…
Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Kids' brain tumor drugs tested for Long-Term safety
Disease control OngoingThis study follows 165 children who previously took dabrafenib and/or trametinib for certain brain tumors. Researchers want to see if these drugs are safe over the long term and how they affect growth. The children continue their treatment and are monitored for side effects and d…
Phase 4 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Could a parasite drug fight childhood brain tumors?
Disease control OngoingThis trial is testing whether mebendazole, a drug commonly used to treat intestinal parasites, can help children with brain tumors called gliomas. The study combines mebendazole with standard chemotherapy drugs to see if it is safe and effective. It includes children and young ad…
Phase 1/2 • Sponsor: Julie Krystal • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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1000 brain tumor Patients' records reviewed to see what worked
Knowledge-focused OngoingThis study is not testing a new treatment. Instead, researchers are reviewing medical records from 1000 adults with recurrent malignant gliomas (aggressive brain tumors) to see how well past chemotherapy and targeted therapies worked. The goal is to learn which treatments are lin…
Sponsor: Blokhin's Russian Cancer Research Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC