Pleomorphic xanthoastrocytoma
MONDO:0016690A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. It presents in the superficial cerebral hemispheres and involves the meninges. It typically affects children and young adults.
Also known as: PXA, pleomorphic Xantho-astrocytoma
1458 clinical trials for this condition and its sub-types, 7 tagged with Pleomorphic xanthoastrocytoma itself.
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Can a targeted pill outperform chemotherapy for childhood brain tumors?
Disease control Recruiting nowThis trial tests whether a daily oral drug called trametinib can better control low-grade gliomas in children and young adults compared to standard weekly vinblastine chemotherapy. The study focuses on patients whose tumors do not have certain genetic changes (BRAF V600 mutation)…
Phase 2 • Sponsor: University Hospital, Strasbourg, France • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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New pill shows promise in early brain tumor trial
Disease control Recruiting nowThis early-stage study tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and check for side effects. About 102 participants will take the drug once or several times a week.
Phase 1 • Sponsor: Jazz Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC