Pleomorphic rhabdomyosarcoma
MONDO:0017386An aggressive malignant mesenchymal neoplasm with skeletal muscle differentiation, occurring in adults and rarely in children. The tumor is characterized by the presence of bizarre round, spindle, and polygonal cells. Clinical presentation includes a rapidly enlarging painful mass usually of the lower extremities.
Also known as: pleomorphic rhabdomyosarcoma
2827 clinical trials for this condition and its sub-types, 7 tagged with Pleomorphic rhabdomyosarcoma itself.
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Sub-types of Pleomorphic rhabdomyosarcoma
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Adult pleomorphic rhabdomyosarcoma 0 trials
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Can a dual immune antibody plus radiation shrink metastatic sarcoma?
Disease control CompletedResearchers are testing a combination of the experimental antibody MEDI5752 and stereotactic body radiotherapy in people with metastatic soft tissue sarcoma that has spread to the lungs. MEDI5752 targets two immune checkpoints, PD-1 and CTLA-4, and the radiation is aimed at one l…
Phase 1 • Sponsor: Institut Claudius Regaud • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Personalized chemo shows promise against rare sarcomas
Disease control CompletedThis Phase 3 trial tested whether giving chemotherapy based on the specific type of soft tissue sarcoma works better than a one-size-fits-all approach. 550 adults with high-risk sarcomas in the arms or trunk were randomly assigned to standard chemo or a chemo regimen matched to t…
Phase 3 • Sponsor: Italian Sarcoma Group • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC