Pleomorphic adenoma
MONDO:0008401A neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It occurs in the parotid gland, submandibular gland, minor salivary glands in the oral cavity, upper respiratory tract, and nasal cavity and paranasal sinuses. It usually presents as a slow growing painless mass. Infrequently, patients may present with pain and facial palsy. It may recur after excision or transform to a malignant neoplasm (carcinoma ex pleomorphic adenoma).
Also known as: adenomas, salivary gland pleomorphic, somatic, pleomorphic adenoma, pleomorphic adenoma (morphologic abnormality), tumor, mixed, benign, Psa, Sgpa, mixed tumor of the salivary gland, mixed tumour of the salivary gland
1468 clinical trials for this condition and its sub-types, 12 tagged with Pleomorphic adenoma itself.
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New drug SPY002-072 aims to tame multiple inflammatory joint diseases
Disease control OngoingThis Phase 2 study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo, and researchers measure changes in disease ac…
Phase 2 • Sponsor: Spyre Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Smarter prostate cancer detection: new combo test aims to reduce unnecessary biopsies
Diagnosis OngoingThis study tests whether combining a special MRI analysis (called Habitat Risk Score) with blood and urine tests can more accurately rule out aggressive prostate cancer than the standard MRI reading. About 289 men with elevated PSA or abnormal exams will be enrolled. The goal is …
Sponsor: University of Miami • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Can a simple blood test outsmart prostate cancer?
Knowledge-focused By invitation onlyThis registry study is collecting blood samples and health data from 1,000 people being evaluated for prostate cancer. The goal is to test the accuracy of a new blood-based test called PROSTest, which looks for genetic signals of prostate cancer activity. Researchers hope this te…
Sponsor: Wren Laboratories LLC • Aim: Knowledge-focused
Last updated Aug 23, 2026 00:00 UTC
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Fatty liver and psoriasis study pulled before it started
Knowledge-focused CancelledThis study aimed to understand the link between non-alcoholic fatty liver disease (NAFLD) and psoriatic disease (psoriasis and psoriatic arthritis) in overweight adults. Researchers planned to use the drug guselkumab (Tremfya) to see if it improved both conditions. However, the t…
Sponsor: University of California, San Diego • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC