Platinum-induced ototoxicity
MONDO:0800178Progressive, bilateral, and irreversible sensorineural hearing loss as a frequently encountered side effect of platinum-based chemotherapy such as cisplatin and carboplatin.
Also known as: deafness, platinum-induced, platinum-related ototoxicity
7 clinical trials for this condition and its sub-types, 4 tagged with Platinum-induced ototoxicity itself.
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Hope for cancer patients: drug may shield ears from chemo damage
Prevention Recruiting nowThis study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…
Phase 2 • Sponsor: Siriraj Hospital • Aim: Prevention
Last updated Jun 27, 2026 08:13 UTC
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Ear gel may shield cancer patients from Chemo-Induced deafness
Prevention Recruiting nowThis study tests whether injecting a special gel (sodium thiosulfate) into the ear before each round of cisplatin chemotherapy can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, so the treated ear can be compared to the untr…
Phase 3 • Sponsor: The Netherlands Cancer Institute • Aim: Prevention
Last updated Jun 27, 2026 08:04 UTC