Pituitary adenocarcinoma

MONDO:0017582

A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas. The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH. The diagnosis is based on the presence of metastases. Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly.

Also known as: cancer of pituitary, cancer of pituitary gland, cancer of the pituitary, cancer of the pituitary gland, pituitary gland cancer, carcinoma of pituitary, carcinoma of pituitary gland, carcinoma of the pituitary

2962 clinical trials for this condition and its sub-types, 3 tagged with Pituitary adenocarcinoma itself.

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Where it sits in the disease tree

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↑ Adenocarcinoma (5243) ↑ Head and neck carcinoma (1415) ↑ Bone carcinoma (131) ↑ Pituitary cancer (4)

Sub-types of Pituitary adenocarcinoma

ACTH-producing pituitary gland carcinoma 0 trials
Pituitary gland basophilic carcinoma 0 trials
Prolactin-producing pituitary gland carcinoma 0 trials

Including sub-types (2962) Tagged with Pituitary adenocarcinoma (3)

Trials to join now! 1 Not yet recruiting 1 Completed 1

Immunotherapy combo shows promise for tough pituitary tumors

Disease control Completed

This phase 2 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 patients with aggressive pituitary tumors that worsened after surgery and radiation. The goal was to see if the combination could shrink tumors or slow their growth. Researchers also monitored side…

Phase 2 • Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Disease control

Last updated Jun 27, 2026 13:01 UTC

Pituitary adenocarcinoma

Where it sits in the disease tree

Immunotherapy combo shows promise for tough pituitary tumors