Pilocytic astrocytoma
MONDO:0016691Pilocytic astrocytoma is a rare subtype of low-grade glioma of the central nervous system characterized by a well circumscribed, often cystic, brain tumor with a discrete mural nodule and long, hair-like projections that extend from the neoplastic astrocytes. Depending on the primary localization and the size of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), blurred vision, decreased visual acuity, ataxia and/or nystagmus, among others. It is most commonly located in the cerebellum, but occurrence in the hypothalamus, brain stem, optic chiasma, and hemispheres has also been reported.
Also known as: astrocytoma, benign, astrocytoma, pilocytic, benign, grade I astrocytic neoplasm, grade I astrocytic tumor, grade I astrocytic tumour, grade I astrocytoma, pilocytic astrocytoma
1465 clinical trials for this condition and its sub-types, 12 tagged with Pilocytic astrocytoma itself.
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Sub-types of Pilocytic astrocytoma
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Pilomyxoid astrocytoma 5 trials
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Childhood pilocytic astrocytoma 1 trial
1 sub-type
- Juvenile pilocytic astrocytoma 0 trials
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Cerebellar pilocytic astrocytoma 0 trials
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Targeted drug pemigatinib tested in brain tumors with specific genetic markers
Disease control Stopped earlyThis phase 2 trial tested the drug pemigatinib in people with recurrent glioblastoma or other brain tumors that have specific changes in FGFR1-3 genes. Participants took a daily tablet for two weeks followed by one week off. The study aimed to see if the drug could shrink tumors,…
Phase 2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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New drug targets genetic weakness in tough cancers
Disease control Stopped earlyThis phase 2 trial tested the drug tovorafenib (DAY101) in 23 people aged 12 and older with recurrent or progressive solid tumors that have specific genetic changes in the MAPK pathway. The goal was to see how many patients' tumors shrank or disappeared. The study was terminated …
Phase 2 • Sponsor: Day One Biopharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:52 UTC
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Spinal tap could replace brain surgery for young tumor patients
Knowledge-focused Stopped earlyThis study looked at whether a liquid biopsy—testing the fluid around the brain and spinal cord—can find tumor DNA in children and young adults with brain tumors. The goal was to see if this safer, non-surgical test could replace risky tissue biopsies for diagnosis and monitoring…
Sponsor: Pediatric Brain Tumor Consortium • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC