Pick disease

MONDO:0008243

A rare neurodegenerative disorder leading to dementia. It is characterized by frontotemporal lobar degeneration with accumulation of tau proteins which form Pick bodies.

Also known as: PICK disease of brain, Pick disease, lobar atrophy of brain, Pick disease of the brain, Pick's disease, dementia with lobar atrophy and neuronal cytoplasmic inclusions, lobar atrophy of the brain

43 clinical trials for this condition and its sub-types, 35 tagged with Pick disease itself.

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Where it sits in the disease tree

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Part of

↑ Cerebral cortex disorder (721) ↑ Frontotemporal dementia (178) ↑ Cerebral degeneration (61)

Including sub-types (43) Tagged with Pick disease (35)

Trials to join now! 12 Not yet recruiting 1 Not yet finished but already full! 10 Completed 11 Terminated 1

Experimental antibody aims to repair brain connections in rare dementia

Disease control Not yet recruiting

This study tests a new drug called NS101 in 15 people with semantic variant primary progressive aphasia (svPPA), a rare type of frontotemporal dementia that affects language and memory. The drug is an antibody designed to help repair connections between brain cells. The main goal…

Phase 2 • Sponsor: Hee-Jin Kim • Aim: Disease control

Last updated Jun 26, 2026 14:05 UTC

Pick disease

Where it sits in the disease tree

Experimental antibody aims to repair brain connections in rare dementia