Persistent truncus arteriosus
MONDO:0018072A rare congenital cardiovascular disorder characterized by the failure of the embryologic structure truncus arteriosus to divide into the aorta and pulmonary trunk. It results in the presence of a single vessel instead of two vessels leading out of the heart. Clinical signs and symptoms include cyanosis that is present at birth, poor growth, dyspnea, tachypnea, arrhythmia, cardiomegaly, and heart failure. If it is not surgically repaired, it leads to death.
Also known as: TAC, Truncus Arteriosus, common aorticopulmonary trunk, common arterial trunk, common truncus arteriosus, persistent truncus arteriosus, persistent truncus arteriosus (disease), truncus arteriosus
84 clinical trials for this condition and its sub-types, 8 tagged with Persistent truncus arteriosus itself.
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Browse by category →Sub-types of Persistent truncus arteriosus
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New balloon treatment aims to keep leg arteries open longer
Disease control Recruiting nowThis study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…
Sponsor: Genoss Co., Ltd. • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New heart valve trial offers hope for patients with rare congenital defects
Disease control Recruiting nowThis study is testing a new heart valve (SAPIEN 3) in 108 people who have a dysfunctional right ventricle outflow tract (RVOT) due to a congenital heart defect or a previous valve replacement. The goal is to see if the valve is safe and effective at improving blood flow and reduc…
Sponsor: Edwards Lifesciences • Aim: Disease control
Last updated Jul 25, 2026 00:00 UTC
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Home workouts could boost heart health for congenital heart patients
Symptom relief Recruiting nowThis study tests whether a 12-week home-based high intensity interval training program can improve exercise capacity in people aged 12 to 45 with a congenital heart defect that required a surgical connection between the right ventricle and pulmonary artery. Participants are rando…
Sponsor: Erasmus Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Could a headset boost brainpower in teens with a rare genetic condition?
Symptom relief Recruiting nowThis study tests whether a gentle brain stimulation technique called tACS, used at home for 5 days a week over 4 weeks, can improve memory and thinking in 40 young people aged 14-25 with 22q11.2 deletion syndrome. The stimulation is personalized based on each participant's MRI an…
Sponsor: Stephan Eliez • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC