Patent foramen ovale
MONDO:0020439A persistent opening in the atrial septum after birth. While a normal part of fetal circulation, the foramen ovale should close once the newborn begins breathing and the pressure in the left atrium exceeds that of the right atrium. While a PFO is generally asymptomatic, it can lead to the passage of clots from the venous circulation into the artierial circulation, resulting in paradoxical emboli, and possible strokes.
Also known as: ostium secundum type atrial septal defect, patent foramen ovale, patent foramen ovale (disease)
111 clinical trials for this condition and its sub-types, 36 tagged with Patent foramen ovale itself.
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Heart device under surveillance: 500 patients tracked for safety
Disease control CompletedThis study followed 500 people who received the Amplatzer PFO Occluder, a device that closes a small hole in the heart called PFO. Researchers tracked serious complications within 30 days and longer-term issues like stroke or blood clots over 3 years. The goal was to confirm the …
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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New catheter system tested for safer heart defect repair
Disease control CompletedThis study tested a new delivery system for implanting devices that close holes in the heart, such as PFO and ASD. It involved 254 patients and measured how well the system worked and how safe it was. The goal was to confirm that the system performs well in real-world use.
Sponsor: Abbott Medical Devices • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Heart hole migraine sufferers: could blood thinners be the answer?
Symptom relief CompletedThis completed Phase 2 trial tested whether blood thinners (rivaroxaban) or antiplatelet drugs (aspirin, clopidogrel) work better than standard migraine medication (metoprolol) for people with both migraine and a small heart hole called PFO. 1,000 participants took one of the fou…
Phase 2 • Sponsor: Chinese Academy of Medical Sciences, Fuwai Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC