Parkinsonian disorder
MONDO:0021095A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.
1311 clinical trials for this condition and its sub-types, 67 tagged with Parkinsonian disorder itself.
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Sub-types of Parkinsonian disorder
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Parkinson disease 1,165 trials · 1,292 incl. sub-types
6 sub-types
- Late-onset Parkinson disease 3 trials · 143 incl. sub-types Sub-types →
- Young-onset Parkinson disease 9 trials · 11 incl. sub-types Sub-types →
- Parkinson disease 16 0 trials
- Parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development 0 trials
- Parkinson disease, mitochondrial 0 trials
- Parkinsonian-pyramidal syndrome 0 trials Sub-types →
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Vascular parkinsonism 4 trials
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Dystonia 12 2 trials
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Perry syndrome 0 trials
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X-linked dystonia-parkinsonism 0 trials
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Atypical juvenile parkinsonism 0 trials
1 sub-type
- Juvenile onset Parkinson disease 19A 0 trials
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Cyanide-induced parkinsonism 0 trials
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Dystonia 16 0 trials
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Encephalitis lethargica 0 trials
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Parkinsonism with polyneuropathy 0 trials
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Parkinsonism-dystonia, infantile 0 trials
3 sub-types
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Postencephalitic Parkinson disease 0 trials
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Primary progressive freezing gait 0 trials
Most studied deeper sub-types
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Free drug access for Parkinson's patients with specific gene mutation
Disease control Expanded access (ended)This program offers continued free access to the experimental drug BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and have already completed the ACTIVATE study. Participants take one 60mg pill daily. The goal is to provide ongoing trea…
Sponsor: Bial R&D Investments, S.A. • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Zapping the brain without surgery: a new hope for Parkinson's?
Disease control By invitation onlyThis study tests a noninvasive technique called temporal interference stimulation (TIS) to see if it can improve motor symptoms in people with Parkinson's disease and related conditions. Participants receive both active and sham stimulation in a random order, with each session la…
Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New pill aims to slow Parkinson's in patients with genetic mutation
Disease control OngoingThis study tests an experimental drug called BIA 28-6156 in people with Parkinson's disease who have a specific change in the GBA1 gene. The goal is to see if the drug can delay the worsening of movement-related daily living skills over 78 weeks. About 237 participants will recei…
Phase 2 • Sponsor: Bial R&D Investments, S.A. • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Heart scan may spot hidden brain disease
Diagnosis By invitation onlyThis study tests whether a special heart scan using a radioactive drug called 123I-MIBG can help identify Lewy body disease, a type of dementia that also affects movement and sleep. Researchers will compare scan results with clinical diagnoses in 50 people who have conditions lik…
Phase 4 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Aug 01, 2026 00:00 UTC
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New PET scan could slash radiation by 100x
Diagnosis By invitation onlyThis study tests a new PET imaging technique that uses 10 to 100 times less radiation than standard scans. Researchers will inject 200 healthy volunteers and patients with a radioactive tracer and use a high-sensitivity scanner to see if image quality remains good enough for dete…
Phase 2 • Sponsor: Akiva Mintz • Aim: Diagnosis
Last updated Jun 27, 2026 12:23 UTC
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Brain scan study aims to sharpen diagnosis of Parkinson's and dementia
Diagnosis By invitation onlyThis study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…
Phase 4 • Sponsor: Mayo Clinic • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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Online support groups and telemedicine aim to ease Parkinson's and dementia burden
Symptom relief OngoingThis study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…
Sponsor: University of Rochester • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Can magnetic pulses ease Parkinson's pain? new trial investigates
Symptom relief By invitation onlyThis study tests whether a non-invasive brain stimulation technique called iTBS can reduce pain and other symptoms in people with Parkinson's disease. Researchers will compare two different stimulation patterns in 90 adults aged 40-80 who have had Parkinson's for at least 3 years…
Sponsor: Second Affiliated Hospital of Soochow University • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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100,000 volunteers join digital brain health study to catch dementia early
Knowledge-focused By invitation onlyThis observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …
Sponsor: Greece 2021 Committee • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Scientists decode gait signatures to spot brain diseases
Knowledge-focused OngoingThis study examines walking patterns in people with Parkinson's disease and similar neurological conditions, as well as healthy volunteers. Researchers aim to identify unique 'gait signatures'—speed-dependent measures of walking—that could help distinguish between different disor…
Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Scientists hunt for clues to diagnose Parkinson's earlier
Knowledge-focused OngoingThis study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…
Sponsor: Non-profit organization for scientific research in Parkinson's disease and related disorders • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Scientists track rare dystonia to map its genetic roots
Knowledge-focused OngoingThis study is observing up to 198 people with rapid-onset dystonia-parkinsonism (RDP) or related genetic mutations. Researchers aim to identify affected individuals, document how common the disease is, and track its progression over time. Participants undergo assessments of sympt…
Sponsor: State University of New York at Buffalo • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Walking study for Parkinson's and stroke patients withdrawn before starting
Knowledge-focused CancelledThis study was designed to test a wearable sensor system that tracks how people walk on different surfaces like grass, pavement, and stairs. It aimed to include healthy volunteers and people with conditions such as Parkinson's disease, dementia, stroke, multiple sclerosis, or low…
Sponsor: University of Leeds • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC