Paranoid schizophrenia
MONDO:0001484A subtype of schizophrenia characterized by prominent delusions (typically persecutory or grandiose) or hallucinations in the context of a relative preservation of cognitive functioning and affect.
Also known as: paranoid type schizophrenia, paraphrenic schizophrenia
85 clinical trials for this condition and its sub-types, 13 tagged with Paranoid schizophrenia itself.
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Can mindfulness ease psychosis in teens and young adults?
Symptom relief Recruiting nowThis study tests whether a 4-week mindfulness group therapy program, added to usual care, can reduce symptoms in 252 young people (ages 16-35) hospitalized for early psychosis. Participants are randomly assigned to either the mindfulness program plus standard treatment or standar…
Sponsor: Stephanie Mehl • Aim: Symptom relief
Last updated Sep 11, 2026 00:00 UTC
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Sleep therapy may ease psychosis in Treatment-Resistant schizophrenia
Symptom relief Recruiting nowThis study tests whether a type of talk therapy focused on sleep (CBT-I) can improve sleep, reduce psychotic symptoms, and enhance quality of life in people with treatment-resistant schizophrenia. About 60 adults with chronic psychosis and long-term sleep problems will receive ei…
Sponsor: Jimmi Nielsen • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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New program aims to give veterans a stronger voice in their own mental health treatment
Knowledge-focused Recruiting nowThis study tests a group program to help veterans with serious mental illness feel more comfortable and confident working with their doctors and therapists. About 119 veterans from three VA centers will take part. The goal is to see if the program improves teamwork between vetera…
Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Can brain scans and eye movements predict psychosis recovery?
Knowledge-focused Recruiting nowThis study looks at 320 people with early psychosis to see if brain scans, eye-tracking, and electrical brain waves can predict how well they respond to treatment. Participants will have four visits over a year, including interviews, memory tests, and optional DNA samples. The go…
Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Scientists hunt for clues to why clozapine works for some with schizophrenia
Knowledge-focused Recruiting nowThis study is looking at 200 people with treatment-resistant schizophrenia who are starting clozapine. Researchers will measure immune markers in blood and spinal fluid, brain scans, and other tests before and after 12 weeks of treatment. The goal is to find biological signs that…
Phase 4 • Sponsor: Jimmi Nielsen • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Could hallucinations in seniors signal dementia? new study investigates
Knowledge-focused Recruiting nowThis study looks at whether older adults who develop hallucinations or delusions for the first time may have early signs of dementia. Researchers will use special brain scans (tau PET) and blood tests to check for abnormal proteins linked to Alzheimer's. The goal is to better und…
Sponsor: Jeremy Koppel • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC