Osteogenesis imperfecta
MONDO:0019019Osteogenesis imperfecta (OI) comprises a heterogeneous group of genetic disorders characterized by increased bone fragility, low bone mass, and susceptibility to bone fractures with variable severity.
Also known as: Lobstein disease, OI, Osteopsathyrosis, Porak and Durante disease, brittle bone disease, glass bone disease, Vrolik disease
330 clinical trials for this condition and its sub-types, 35 tagged with Osteogenesis imperfecta itself.
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Sub-types of Osteogenesis imperfecta
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Osteogenesis imperfecta and a reduction of bone mineral density. 0 trials · 308 incl. sub-types
34 sub-types
- Osteoporosis 278 trials · 296 incl. sub-types Sub-types →
- Osteogenesis imperfecta type 3 9 trials
- Osteogenesis imperfecta type 1 8 trials Sub-types →
- Osteogenesis imperfecta type 4 7 trials
- Osteogenesis imperfecta type 5 1 trial
- Bruck syndrome 2 0 trials
- Cole-Carpenter syndrome 1 0 trials
- Cole-Carpenter syndrome 2 0 trials
- Ehlers-Danlos syndrome, spondylodysplastic type, 1 0 trials
- Singleton-Merten syndrome 1 0 trials
- Singleton-Merten syndrome 2 0 trials
- Wiedemann-Rautenstrauch syndrome 0 trials
- Autosomal recessive cutis laxa type 2A 0 trials Sub-types →
- Autosomal recessive cutis laxa type 2B 0 trials
- Calvarial doughnut lesions-bone fragility syndrome 0 trials
- Geroderma osteodysplastica 0 trials
- Gnathodiaphyseal dysplasia 0 trials
- Osteogenesis imperfecta type 10 0 trials
- Osteogenesis imperfecta type 11 0 trials
- Osteogenesis imperfecta type 12 0 trials
- Osteogenesis imperfecta type 14 0 trials
- Osteogenesis imperfecta type 15 0 trials
- Osteogenesis imperfecta type 16 0 trials
- Osteogenesis imperfecta type 17 0 trials
- Osteogenesis imperfecta type 2 0 trials
- Osteogenesis imperfecta type 6 0 trials
- Osteogenesis imperfecta type 7 0 trials
- Osteogenesis imperfecta type 8 0 trials
- Osteogenesis imperfecta type 9 0 trials
- Osteogenesis imperfecta, type 18 0 trials
- Osteogenesis imperfecta, type 19 0 trials
- Osteoporosis-pseudoglioma syndrome 0 trials
- Short stature-optic atrophy-Pelger-Huët anomaly syndrome 0 trials
- Spondylo-ocular syndrome 0 trials
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Brittle bone disorder 4 trials
1 sub-type
- Brittle bone syndrome lethal type 0 trials
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Osteogenesis imperfecta type 13 0 trials
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Osteogenesis imperfecta, IIA 22 0 trials
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Osteogenesis imperfecta, type 20 0 trials
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Osteogenesis imperfecta, type 21 0 trials
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Osteogenesis imperfecta, type 23 0 trials
Most studied deeper sub-types
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Brittle bone breakthrough? new drug combo aims to cut fractures
Disease control CompletedThis study tested whether a two-year course of teriparatide (a bone-building drug) followed by a single infusion of zoledronic acid (a bone-strengthening drug) could reduce fractures in adults with osteogenesis imperfecta, also known as brittle bone disease. 350 participants were…
Phase 4 • Sponsor: University of Edinburgh • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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New nail tested for kids with brittle bones
Disease control CompletedThis study looked at how well a special telescopic nail (JuniOrtho) works and how safe it is in children with osteogenesis imperfecta (brittle bone disease). Fourteen children aged 18 months to 18 years who needed surgery for broken bones or bone straightening took part. The main…
Sponsor: Orthofix s.r.l. • Aim: Disease control
Last updated Jun 27, 2026 08:14 UTC
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Hands-On relief: which therapy eases knee arthritis pain best?
Symptom relief CompletedThis study compares two hands-on therapy techniques—joint distraction and passive end-range overpressure—for people with knee osteoarthritis. Participants, aged 40 to 60 with moderate knee pain, receive one of the two treatments over four weeks. The goal is to see which approach …
Sponsor: University of Faisalabad • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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Gentle exercise shows promise for kids with brittle bones
Symptom relief CompletedThis study looked at whether a supervised, adapted exercise program can improve fitness and quality of life in children aged 6 to 18 with osteogenesis imperfecta, a rare genetic condition causing fragile bones. Thirty participants did 30-minute exercise sessions twice a week for …
Sponsor: Hospices Civils de Lyon • Aim: Symptom relief
Last updated Jun 26, 2026 16:43 UTC
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Researchers track rare bone disorder in kids to uncover clues
Knowledge-focused CompletedThis study followed 46 children with osteogenesis imperfecta (OI), a rare connective tissue disorder that causes frequent fractures and short stature. Researchers collected medical history, physical exams, hearing and dental tests, X-rays, bone scans, and genetic samples over sev…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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Long-Term study aims to unlock secrets of brittle bone disease
Knowledge-focused CompletedThis study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Researchers observe bone disorders to expand knowledge
Knowledge-focused CompletedThis study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Wearable sensors shed light on movement in brittle bone disease
Knowledge-focused CompletedThis completed study enrolled 33 people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers used special sensors and gait analysis to measure how participants move. The goal was to identify which movement patterns are most useful for understanding…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Blood clues may unlock mystery of brittle bone disease severity
Knowledge-focused CompletedThis study looked at 66 adults with Osteogenesis Imperfecta (brittle bone disease) to see if small molecules called microRNAs in the blood are linked to how severe the condition is. Researchers compared people with mild (type 1) and severe (type 3) forms, plus healthy controls. T…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:34 UTC