Opioid abuse

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

Researchers at Yale are testing a decision-support tool called EMBED CDS that alerts emergency department doctors when a patient with opioid use disorder might be eligible for buprenorphine, a medication that eases withdrawal and cravings. The study involves 100 adults with moder…

This trial tests whether a brief psychological intervention—combining education, mindfulness, and acceptance-based strategies—can help people who have had a musculoskeletal injury reduce their opioid use and avoid developing chronic pain. The study enrolls adults admitted to the …

This study tests a brief psychological program designed to help people who have been hospitalized with a musculoskeletal injury and prescribed opioids. The program includes education about long-term opioid use and mindfulness-based strategies, delivered through a computer session…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests a nerve block given during minimally invasive colorectal surgery to see if it reduces pain and the need for opioids. Researchers will track 400 adults having left-sided colon or rectal surgery. The goal is to improve recovery and reduce side effects like nausea.

This study tests a training program called Project ECHO to help rural jails start or increase use of medications (methadone, buprenorphine, naltrexone) for opioid use disorder. Staff from 40 jails will attend online sessions with experts and peers over 18 months. Researchers will…

This study looks at how kratom affects people who have used opioids in the past. Researchers will compare kratom to another substance and a placebo to see how the body processes it and what effects it has. The goal is to better understand the potential risks and benefits of krato…

This study tests a 12-week Instagram program led by trained peers to help young adults (ages 18-25) who misuse prescription opioids. Participants will receive interactive modules and support via private Instagram groups. The goal is to see if the program is engaging, acceptable, …

This study looks at how opioid use affects oxidative stress in adults. Researchers will collect blood samples and health information from 120 people taking opioids like morphine or fentanyl. No new treatments are given. The goal is to better understand the biological effects of o…

This study tests whether a special child-resistant blister pack with clear labeling can help reduce how many opioid pills are prescribed and used after orthopedic surgery. About 352 adults will receive either the new packaging or the standard orange bottle. Researchers will track…