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Olmsted syndrome

MONDO:0031421

A hereditary palmoplantar keratoderma characterized by the combination of bilateral mutilating transgredient palmoplantar keratoderma and periorificial keratotic plaques.

Also known as: mutilating palmoplantar hyperkeratosis with periorificial keratotic plaques, palmoplantar and periorificial keratoderma, palmoplantar keratoderma, mutilating, with periorificial keratotic plaques

1 clinical trial for this condition and its sub-types, 1 tagged with Olmsted syndrome itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary palmoplantar keratoderma (13)

Sub-types of Olmsted syndrome

Including sub-types (1) Tagged with Olmsted syndrome (1)

Trials to join now! 1

New pill could ease rare skin disease

Disease control Recruiting now

This early-stage trial tests an oral drug called KM-023 for Olmsted Syndrome, a rare genetic condition causing painful, thick skin on the palms and soles. First, healthy volunteers will receive single or multiple doses to check safety and how the body handles the drug. Then, pati…

Phase 1 • Sponsor: Orvida Pharma (formerly Kamari Pharma) • Aim: Disease control

Last updated Jun 27, 2026 12:36 UTC

Olmsted syndrome

Where it sits in the disease tree

New pill could ease rare skin disease