Nut midline carcinoma
MONDO:0005563A rare, highly aggressive and lethal carcinoma that affects children and young adults. It arises from midline epithelial structures, most commonly the head, neck, and mediastinum. It is a poorly differentiated carcinoma and is characterized by mutations and rearrangement of the NUT gene. A balanced translocation t(15;19) is present that results in the creation of a fusion gene involving the NUT gene, most commonly BRD4-NUT fusion gene.
Also known as: Midline carcinoma of children and Young adults with NUT rearrangement, NMC, NUT Midline carcinoma, NUT carcinoma, carcinoma with t(15;19)(q13;p13.1) translocation, nuclear protein in testis midline carcinoma, NUT midline carcinoma of the head and neck
2751 clinical trials for this condition and its sub-types, 6 tagged with Nut midline carcinoma itself.
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Rare lung cancer under the microscope: what can past cases teach us?
Knowledge-focused OngoingThis study is gathering information from medical records of 150 people with a rare lung cancer called NUT carcinoma. Researchers want to see what treatments patients received in real life and how they fared over time. No new treatments are being tested; instead, the goal is to le…
Sponsor: Three Gorges Hospital of Chongqing University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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New screening could open door to T-Cell therapy for Hard-to-Treat cancers
Knowledge-focused OngoingThis study screens up to 1,150 people with advanced solid tumors like head and neck, cervical, or lung cancer. Researchers test blood and tumor samples to see if participants have the right genetic markers for future T-cell therapy trials. The goal is to find who might benefit fr…
Sponsor: TScan Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC