Nodular lymphocyte predominant Hodgkin lymphoma
MONDO:0044778A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)
Also known as: Hodgkin lymphoma nodular LP, NOS, Hodgkin lymphoma nodular lymphocyte predominant type, NOS, NLPHL, nodular lymphocyte predominant Hodgkin lymphoma, nodular lymphocyte predominant Hodgkin's lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma
1904 clinical trials for this condition and its sub-types, 5 tagged with Nodular lymphocyte predominant Hodgkin lymphoma itself.
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Sub-types of Nodular lymphocyte predominant Hodgkin lymphoma
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New drug mosunetuzumab takes on rituximab in rare lymphoma trial
Disease control Recruiting nowThis phase 2 trial tests whether mosunetuzumab, a newer antibody, works better than the standard rituximab for nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). About 70 patients with untreated or previously treated NLPHL will receive one of the two drugs. The main goal is…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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New study aims to hear from NLPHL patients about their Real-Life experiences
Knowledge-focused Recruiting nowThis study collects information directly from people (ages 8 and older) with nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) about their symptoms and quality of life. Participants will fill out surveys over time to help researchers understand how the disease and its treat…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:35 UTC