Nodal marginal zone B-cell lymphoma
MONDO:0019465Nodal marginal zone B-cell lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma, characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement of the lymph nodes, sometimes the bone marrow, and rarely the blood. Clinically it presents with disseminated peripheral, abdominal and/or thoracic lymphadenopathy. Cytopenia and bulky tumors (greater than 5 cm) are rare. Association with Hepatitis C virus and chronic inflammation has been reported.
Also known as: Monocytoid B-cell lymphoma, NMZL, nodal marginal zone B-cell lymph., nodal marginal zone B-cell lymphoma, nodal marginal zone lymphoma
2015 clinical trials for this condition and its sub-types, 16 tagged with Nodal marginal zone B-cell lymphoma itself.
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New hope for tough lymphoma: Three-Drug showdown begins
Disease control Not yet recruitingThis phase II trial tests whether a drug called mosunetuzumab works better alone or combined with either zanubrutinib or polatuzumab vedotin for people with marginal zone lymphoma that has returned or stopped responding to treatment. The study will enroll 138 participants and mea…
Phase 2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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New drug duo targets hard-to-treat lymphoma
Disease control Not yet recruitingThis study tests a combination of two drugs, nemtabrutinib and rituximab, in about 35 adults with marginal zone lymphoma, a slow-growing blood cancer. The goal is to see if the combo is safe and can shrink or eliminate tumors. Participants will receive the drugs by mouth and thro…
Phase 2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC