Neurofibromatosis
MONDO:0021061A hereditary neoplastic syndrome in which tumors grow in the nervous system. There are typically 3 main types recognized, but other forms with uncertain etiology exist.
Also known as: Recklinghausen's neurofibromatosis, acoustic neurofibromatosis, central Neurofibromatosis, neurofibromatosis, neurofibromatosis syndrome, peripheral Neurofibromatosis, type IV neurofibromatosis of riccardi, von Reklinghausen disease
125 clinical trials for this condition and its sub-types, 19 tagged with Neurofibromatosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Neurofibromatosis
-
Neurofibromatosis type 1 73 trials
3 sub-types
-
NF2-related schwannomatosis 21 trials
-
Schwannomatosis 3 trials
4 sub-types
- 22q-related schwannomatosis 0 trials
- LZTR1-related schwannomatosis 0 trials
- SMARCB1-related schwannomatosis 0 trials
- Neurofibromatosis, type III, mixed central and peripheral 0 trials
-
Neurofibromatosis-Noonan syndrome 2 trials
1 sub-type
- Watson syndrome 0 trials
-
New drug shows promise for shrinking painful NF1 tumors
Disease control OngoingThis study tests a drug called mirdametinib in 114 adults and children with a genetic condition called NF1 that causes nerve tumors (plexiform neurofibromas) that cannot be removed by surgery and cause serious problems. The drug works by blocking a protein that helps tumors grow.…
Phase 2 • Sponsor: SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, Germany • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
-
Laser zaps NF1 skin bumps in small trial
Symptom relief PausedThis study tests whether monthly alexandrite laser treatments can safely shrink or improve the look of skin tumors in adults with neurofibromatosis type 1 (NF1). Ten participants will receive up to six monthly laser sessions, with some areas treated with cooling and others withou…
Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
-
500 NF1 patients join study to track skin tumors over 5 years
Knowledge-focused OngoingThis study follows 500 people with neurofibromatosis type 1 (NF1) to see how their skin tumors (called cutaneous neurofibromas) grow and change over time. Researchers use 3D whole-body photography to track tumor number and size each year. The goal is to better understand these tu…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC