Netherton syndrome
MONDO:0009735Netherton syndrome (NS) is a skin disorder characterized by congenital ichthyosiform erythroderma (CIE), a distinctive hair shaft defect (trichorrhexis invaginata; TI) and atopic manifestations.
Also known as: Comèl-Netherton syndrome, Ichthyosis, Netherton Syndrome, NS, Netherton syndrome, bamboo hair syndrome, Comel-Netherton syndrome, Netherton disease, erythroderma, ichthyosiform, with hypotrichosis and hyper-IgE
60 clinical trials for this condition and its sub-types, 16 tagged with Netherton syndrome itself.
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Can a skin lotion tame the symptoms of a rare genetic disease?
Disease control Recruiting nowThis trial tests whether QRX003, a lotion applied to the skin, can reduce the redness, scaling, and itch caused by Netherton syndrome, a rare genetic condition. Participants apply the lotion twice daily for 3 months and visit the clinic every 4 to 6 weeks for checkups. The study …
Phase 2/3 • Sponsor: Quoin Pharmaceuticals • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Can a lotion calm the severe skin symptoms of netherton syndrome?
Disease control Recruiting nowThis trial tests whether QRX003 lotion, applied to the skin, can safely reduce the severity of Netherton syndrome, a rare genetic condition causing red, scaly skin and intense itching. Researchers will enroll about 20 people aged 14 and older who have the condition. Participants …
Phase 2/3 • Sponsor: Quoin Pharmaceuticals • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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New drug trial hopes to tame rare skin disease
Disease control Recruiting nowThis early-stage trial tests a new drug called BCX17725 in healthy volunteers and people with Netherton syndrome, a rare genetic skin condition. The study aims to check safety, how the drug moves through the body, and whether it can reduce skin redness and scaling. About 78 parti…
Phase 1 • Sponsor: BioCryst Pharmaceuticals • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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New lotion shows promise for rare skin disorder
Disease control Recruiting nowThis study tests a lotion called QRX003 in people with Netherton Syndrome, a rare genetic skin condition. About 16 participants aged 4 and older will apply the lotion twice daily for 12 weeks. Researchers will check if it improves skin appearance and reduces itching.
Phase 2/3 • Sponsor: Quoin Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Microbiome study seeks clues in rare skin condition
Knowledge-focused Recruiting nowThis study looks at the bacteria, fungi, and viruses living on the skin, in the gut, and in the mouth of people with Netherton syndrome, a rare condition that damages the skin barrier and often causes allergies. Researchers will compare these microbes to those of healthy voluntee…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC