Netherton syndrome
MONDO:0009735Netherton syndrome (NS) is a skin disorder characterized by congenital ichthyosiform erythroderma (CIE), a distinctive hair shaft defect (trichorrhexis invaginata; TI) and atopic manifestations.
Also known as: Comèl-Netherton syndrome, Ichthyosis, Netherton Syndrome, NS, Netherton syndrome, bamboo hair syndrome, Comel-Netherton syndrome, Netherton disease, erythroderma, ichthyosiform, with hypotrichosis and hyper-IgE
60 clinical trials for this condition and its sub-types, 16 tagged with Netherton syndrome itself.
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Live bacteria cream shows promise for rare skin disease
Disease control CompletedThis early-stage trial tests a cream called ATR12-351 for Netherton syndrome, a rare genetic skin condition. The cream contains live bacteria that produce a protein missing in people with the disease. Twelve adults will apply the cream to one side of their body and a placebo to t…
Phase 1 • Sponsor: Azitra Inc. • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Could arthritis drug humira ease rare skin disease?
Disease control CompletedThis Phase 2 trial tested whether Humira (adalimumab), a drug used for arthritis, can help people with Netherton syndrome, a rare genetic skin condition that causes severe inflammation, itching, and pain. Eleven patients received six injections over three months, followed by thre…
Phase 2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New cream shows promise for rare skin condition
Disease control CompletedThis early study tested a cream called SXR1096 on 9 people with Netherton syndrome, a rare inflammatory skin disease. The cream aims to block certain enzymes that cause skin problems. Participants applied the cream and a placebo to different skin areas for one month to check safe…
Phase 1/2 • Sponsor: Sixera Pharma • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Drug combo shows promise for rare skin disease in kids
Disease control CompletedThis study tested a combination of two immune-targeting drugs, secukinumab and dupilumab, in 15 children with severe Netherton syndrome, a rare genetic skin disorder. The goal was to see if the treatment could improve survival and control the disease. The children received weight…
Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology • Aim: Disease control
Last updated Jun 26, 2026 13:45 UTC
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Rare skin disease mystery unraveled: new study maps netherton Syndrome's inner workings
Knowledge-focused CompletedThis study looked at Netherton syndrome, a rare genetic skin condition, to better understand how it affects the body and immune system. Researchers studied 18 people with the disease, measuring immune markers in the blood and tracking skin changes. The goal was to find new target…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC