Neoplasm of mature B-cells

MONDO:0004949

A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Also known as: mature B-cell lymphocytic neoplasm, mature B-cell neoplasm, mature B-cell neoplasms

4517 clinical trials for this condition and its sub-types, 14 tagged with Neoplasm of mature B-cells itself.

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Where it sits in the disease tree

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↑ B-cell neoplasm (3174)

Sub-types of Neoplasm of mature B-cells

Plasma cell neoplasm 108 trials · 1,151 incl. sub-types
7 sub-types
- Plasma cell myeloma 1,108 trials · 1,131 incl. sub-types Sub-types →
- Refractory plasma cell neoplasm 228 trials
- Plasma cell leukemia 32 trials
- Plasmacytoma 9 trials · 17 incl. sub-types Sub-types →
- Non-amyloid monoclonal immunoglobulin deposition disease 3 trials · 11 incl. sub-types Sub-types →
- Heavy chain disease 1 trial · 2 incl. sub-types Sub-types →
- Leukemoid reaction 0 trials
Diffuse large B-cell lymphoma 633 trials · 755 incl. sub-types
30 sub-types
- Relapsed/refractory diffuse large B-cell lymphoma 210 trials
- High grade B-cell lymphoma 185 trials
- Primary mediastinal large B-cell lymphoma 175 trials
- T-cell/histiocyte rich large B cell lymphoma 31 trials
- Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly 23 trials
- Diffuse large B-cell lymphoma of the central nervous system 21 trials
- Plasmablastic lymphoma 20 trials
- Primary effusion lymphoma 18 trials
- Diffuse large B-cell lymphoma germinal center B-cell type 13 trials
- Diffuse large B-cell lymphoma activated B-cell type 9 trials
- Lymphomatoid granulomatosis 3 trials · 7 incl. sub-types Sub-types →
- Primary cutaneous diffuse large B-cell lymphoma, Leg type 7 trials
- ALK-positive large B-cell lymphoma 5 trials
- Intravascular large B-cell lymphoma 4 trials
- Diffuse large B-cell lymphoma with chronic inflammation 3 trials
- Primary vitreoretinal large b-cell lymphoma 3 trials
- EZB diffuse large B-cell lymphoma 0 trials · 2 incl. sub-types Sub-types →
- MCD diffuse large B-cell lymphoma 1 trial
- Breast diffuse large B-cell lymphoma 1 trial
- A53 diffuse large B-cell lymphoma 0 trials
- BN2 diffuse large B-cell lymphoma 0 trials
- N1 diffuse large B-cell lymphoma 0 trials
- ST2 diffuse large B-cell lymphoma 0 trials
- Colorectal diffuse large B-cell lymphoma 0 trials
- Gastric diffuse large B-cell lymphoma 0 trials
- Liver diffuse large B-cell lymphoma 0 trials
- Primary pulmonary diffuse large B-cell lymphoma 0 trials
- Small intestinal diffuse large B-cell lymphoma 0 trials
- Splenic diffuse large B-cell lymphoma 0 trials
- Thyroid gland diffuse large B-cell lymphoma 0 trials
Follicular lymphoma 590 trials
B-cell chronic lymphocytic leukemia 509 trials · 538 incl. sub-types
2 sub-types
- Chronic lymphocytic leukemia/small lymphocytic lymphoma 108 trials · 109 incl. sub-types Sub-types →
- Hairy cell leukemia 40 trials Sub-types →
Burkitt lymphoma 221 trials
2 sub-types
- Colon Burkitt lymphoma 0 trials
- Small intestinal Burkitt lymphoma 0 trials
Primary central nervous system lymphoma 92 trials · 103 incl. sub-types
3 sub-types
- Central nervous system non-hodgkin lymphoma 1 trial · 22 incl. sub-types Sub-types →
- Cerebral lymphoma 2 trials
- Spinal cord lymphoma 0 trials
MALT lymphoma 30 trials · 31 incl. sub-types
5 sub-types
- Gastric mucosa-associated lymphoid tissue lymphoma 2 trials
- Breast mucosa-associated lymphoid tissue lymphoma 0 trials
- Small intestinal mucosa-associated lymphoid tissue lymphoma 0 trials
- Thyroid gland mucosa-associated lymphoid tissue lymphoma 0 trials
- Tonsillar lymphoma 0 trials
B-cell prolymphocytic leukemia 7 trials

Most studied deeper sub-types

Smoldering plasma cell myeloma (63) Hairy cell leukemia variant (9) Refractory hairy cell leukemia (9) Light chain deposition disease (8) Extramedullary plasmacytoma (7) Grade III lymphomatoid granulomatosis (4) Solitary osseous plasmacytoma (4) EZB-MYC+ diffuse large B-cell lymphoma (2) Heavy chain deposition disease (2) Pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma (2) Primary plasmacytoma of the bone (2) Alpha-heavy chain disease (1) Indolent plasma cell myeloma (1) Non-secretory plasma cell myeloma (1) Central nervous system anaplastic large cell lymphoma (0) Chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation (0) Delta-heavy chain disease (0) Epsilon-heavy chain disease (0) Extramedullary soft tissue plasmacytoma (0) EZB-MYC- diffuse large B-cell lymphoma (0)

Including sub-types (4517) Tagged with Neoplasm of mature B-cells (14)

Trials to join now! 4 Not yet recruiting 4 Not yet finished but already full! 2 Completed 4

Neoplasm of mature B-cells

Where it sits in the disease tree

Most studied deeper sub-types

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