Nasal cavity polyp

This study tests a nasal spray called OPN-375 in about 72 teenagers (ages 12-17) who have nasal polyps—growths inside the nose that cause stuffiness and breathing trouble. The spray is given twice a day for 16 weeks, and some participants receive a placebo (inactive spray) for co…

Researchers are testing an experimental antibody drug called verekitug in adults with chronic rhinosinusitis with nasal polyps, a condition where inflamed tissue grows inside the nasal passages and causes congestion. Participants receive either verekitug or a placebo injection wh…

This study looked at how dupilumab, a drug that blocks certain immune signals, improves smell in adults with chronic sinusitis and nasal polyps. Researchers measured changes in inflammation in the smell region using CT scans, endoscopy, and mucus samples over three months. The go…

This phase 3 trial tests whether mepolizumab, an injectable drug, can reduce nasal polyp size and improve symptoms like nasal blockage in adults with chronic rhinosinusitis and nasal polyps. Participants receive either mepolizumab or a placebo every four weeks for a year. The stu…

This phase 3 trial tests whether mepolizumab, an injectable antibody that calms a type of immune cell, can reduce nasal polyp size and improve breathing when added to standard nasal spray therapy. About 400 adults with severe bilateral nasal polyps will receive either mepolizumab…

This phase 3 trial tested tezepelumab, a biologic drug given as a shot, in 416 adults with severe chronic sinusitis and nasal polyps. Participants received either tezepelumab or a placebo, plus a standard nasal steroid spray. The study measured changes in polyp size and nasal con…

This phase 3 trial tested a biologic drug called depemokimab in 276 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as an injection under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks to see …

This study compared two types of sinus surgery for people with chronic sinusitis and nasal polyps that involve a type of inflammation called eosinophilic. One surgery (MRESS) removes more tissue, including the middle turbinate, while the standard surgery (FESS) preserves it. The …

This Phase 3 trial tested a biologic drug called depemokimab in 264 adults with chronic sinusitis and nasal polyps. Participants received either the drug or a placebo as a shot under the skin. The study measured changes in polyp size and nasal blockage over 52 weeks. The goal is …

This study looked at whether using computer-assisted navigation during sinus surgery helps people with nasal polyps. Researchers compared surgery with and without this technology in 40 patients. They tracked how often polyps came back and how many complications occurred.

This study looked at how mepolizumab, a biologic drug, changes inflammation in people with severe eosinophilic asthma. Researchers measured immune and metabolic markers in the nose, lungs, and blood of 15 adults. The goal was to better understand the drug's full impact beyond jus…

This study looked at how a molecule called IL-5 affects different cells in the sinuses of people with nasal polyps and a related condition called aspirin-exacerbated respiratory disease. Researchers analyzed tissue samples from 30 participants to understand how IL-5 contributes t…