Myeloid leukemia associated with down syndrome
MONDO:0850271An acute megakaryocytic leukemia occurring in children with Down syndrome and that has material basis in mutation in the GATA1 gene.
3085 clinical trials for this condition and its sub-types, 5 tagged with Myeloid leukemia associated with down syndrome itself.
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Can tailored chemotherapy tame leukemia in down syndrome?
Disease control OngoingThis phase 3 trial is testing whether adjusting chemotherapy based on a child's early response can improve outcomes for acute myeloid leukemia (AML) or myelodysplastic syndrome in children with Down syndrome. After the first round of treatment, patients are placed into risk group…
Phase 3 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Aug 21, 2026 00:00 UTC
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New hope for tough leukemia: drug combo targets hidden cancer cells
Disease control OngoingThis early-phase study tests a new drug called uproleselan combined with two standard chemotherapy drugs for children and teens with acute myeloid leukemia or related blood cancers that have returned or not responded to treatment. The drug works by blocking a protein that helps c…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC