Multicentric Castleman disease

MONDO:0019754

Multicentric castleman disease (MCD) is an aggressive form of Castleman disease that mostly results from human herpesvirus 8 (HHV8) infection. It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.

Also known as: HHV-8-associated multicentric Castleman disease, Human herpesvirus-8-associated multicentric Castleman disease, MCD, multicentric Angiofollicular lymphoid hyperplasia, multicentric Castleman's disease, idiopathic multicentric Castleman's disease, multicentric plasma cell variant of Castleman's disease

1487 clinical trials for this condition and its sub-types, 13 tagged with Multicentric Castleman disease itself.

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Where it sits in the disease tree

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Part of

↑ Human herpesvirus 8-related tumor (64) ↑ Castleman disease (18)

Including sub-types (1487) Tagged with Multicentric Castleman disease (13)

Trials to join now! 7 Not yet finished but already full! 5 Completed 1

New hope for rare disease: rituximab trial in malawi

Disease control Completed

This phase II trial tests the drug rituximab (Rituxan) as a first treatment for multicentric Castleman disease, a rare immune disorder, in 15 adults in Malawi. Some high-risk patients also receive etoposide. The study aims to see if rituximab is safe and works better than standar…

Phase 2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control

Last updated Aug 01, 2026 00:00 UTC

Multicentric Castleman disease

Where it sits in the disease tree

New hope for rare disease: rituximab trial in malawi