Muckle-Wells syndrome
MONDO:0008633An intermediate form of cryopyrin-associated periodic syndrome (CAPS) and is characterized by recurrent fever (with malaise and chills), recurrent urticaria-like skin rash, sensorineural deafness, general signs of inflammation (eye redness, headaches, arthralgia/myalgia) and potentially life-threatening secondary amyloidosis (AA type).
Also known as: Muckle-Wells syndrome, neutrophilic urticaria, Cryopyrin-associated periodic syndrome 2, MUCKLE-Wells syndrome, MWS, Muckle Wells syndrome, Uda syndrome, urticaria, deafness and amyloidosis
14 clinical trials for this condition and its sub-types, 3 tagged with Muckle-Wells syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →-
New CAPS pill enters first human tests
Disease control Recruiting nowThis early-phase trial is testing an experimental drug called JTE-162 in 5 adults with CAPS, a rare condition that causes fever, rash, and joint pain. Participants take one tablet daily for 2 weeks. Researchers will check if the drug safely reduces inflammation and improves sympt…
Phase 1 • Sponsor: Akros Pharma Inc. • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
-
New scan could reveal hidden organ damage without a biopsy
Diagnosis Recruiting nowThis study tests a radioactive tracer called 124I-AT-01 that binds to amyloid clumps in the body. Researchers want to see if PET/CT scans can detect amyloidosis in organs of people with CAPS who developed it from anakinra injections. Thirty adults will be scanned every 6 months f…
Phase 1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Diagnosis
Last updated Jun 27, 2026 12:35 UTC
-
Could your body clock affect rare inflammatory disease?
Knowledge-focused Recruiting nowThis study looks at whether people with CAPS (a rare genetic inflammatory condition) have disrupted circadian rhythms—the body's natural day-night cycle. Researchers will measure melatonin levels and track activity with a watch in 30 participants (patients and healthy household m…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC