Mobius syndrome

MONDO:0008006

Moebius syndrome is a very rare congenital cranial dysinnervation disorder characterized by complete or incomplete facial paralysis in association with bilateral palsy of the abducens nerve causing impairment of ocular abduction. The syndrome also includes various other congenital anomalies.

Also known as: MBS, Mobius syndrome, Moebius Syndrome, Moebius sequence, Moebius syndrome, Moebius syndrome, Isolated cases, Möbius syndrome, congenital facial diplegia

2 clinical trials for this condition and its sub-types, 2 tagged with Mobius syndrome itself.

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Where it sits in the disease tree

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↑ Syndromic disease (7158) ↑ Congenital nervous system disorder (287) ↑ Multiple congenital anomalies/dysmorphic syndrome-variable intellectual disability syndrome (91) ↑ Facial nerve disorder (53) ↑ Nuclear oculomotor paralysis (8)

Sub-types of Mobius syndrome

Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome 0 trials

Including sub-types (2) Tagged with Mobius syndrome (2)

Trials to join now! 1 Completed 1

Scientists dive into the genetics of moebius syndrome

Knowledge-focused Completed

This completed study by the National Human Genome Research Institute looked at 207 people with Moebius syndrome or similar congenital facial weakness disorders, along with their family members. Researchers aimed to better understand the genetic and clinical features of these cond…

Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused

Last updated Sep 03, 2026 00:00 UTC

Mobius syndrome

Where it sits in the disease tree

Scientists dive into the genetics of moebius syndrome