MELAS syndrome
MONDO:0010789MELAS (Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) syndrome is a rare progressive multisystemic disorder characterized by encephalomyopathy, lactic acidosis, and stroke-like episodes. Other features include endocrinopathy, heart disease, diabetes, hearing loss, and neurological and psychiatric manifestations.
Also known as: MELAS syndrome, mitochondrial encephalomyopathy, lactic acidosis and stroke, mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes, mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes, mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, MELAS, mitochondrial encephalomyopathy lactic acidosis and stroke-like episodes
26 clinical trials for this condition and its sub-types, 13 tagged with MELAS syndrome itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of MELAS syndrome
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Can a common antioxidant help mitochondrial disease?
Disease control Recruiting nowThis phase 1 trial tests N-acetylcysteine (NAC), an antioxidant, in 18 adults with a specific mitochondrial disease caused by the m.3243A>G mutation and low brain glutathione levels. Participants take one of three daily doses (1800, 3600, or 5400 mg) for 3 months to find the safe…
Phase 1 • Sponsor: Michio Hirano, MD • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Hope for mitochondrial disease: new drug targets debilitating fatigue
Symptom relief Recruiting nowThis study tests whether the drug sonlicromanol can reduce fatigue and improve physical abilities like balance and leg strength in adults with a specific genetic form of mitochondrial disease. About 220 participants will take either the drug or a placebo twice daily for 52 weeks.…
Phase 3 • Sponsor: Khondrion BV • Aim: Symptom relief
Last updated Jul 01, 2026 00:00 UTC
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Worldwide data pool could pave the way for mitochondrial disease trials
Knowledge-focused Recruiting nowThis study creates a global registry for people with mitochondrial disorders—rare diseases that affect energy production in cells. By collecting health data from 6,000 participants worldwide, researchers aim to understand how these diseases progress and identify the best ways to …
Sponsor: LMU Klinikum • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Scientists launch massive mitochondrial disease registry to unlock secrets of rare disorders
Knowledge-focused Recruiting nowThis study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists observe mitochondrial mutation carriers to unlock disease secrets
Knowledge-focused Recruiting nowThis study follows 300 people who carry a specific mitochondrial DNA mutation (m.3243A>G) that can cause symptoms like migraines, seizures, and hearing loss. Researchers will use brain scans, muscle tests, and cognitive assessments to track how the disease progresses over time. N…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC