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Melancholia
MONDO:0002444A subtype of depression characterized by the inability to find pleasure in positive things combined with physical agitation, insomnia, or decreased appetite.
Also known as: depression with melancholic features, melancholic depression
56 clinical trials for this condition and its sub-types, 3 tagged with Melancholia itself.
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Zapping two brain regions may restore pleasure in depression
Symptom relief Recruiting nowResearchers are testing whether a form of magnetic brain stimulation called intermittent theta-burst stimulation (iTBS) can improve anhedonia, the inability to feel pleasure, in people with major depression. The study compares stimulating two brain areas at once (the left dorsola…
Sponsor: Guo Wenbin • Aim: Symptom relief
Last updated Sep 12, 2026 00:00 UTC
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Zapping a nerve in the ear might boost motivation and reduce anxiety
Knowledge-focused Recruiting nowThis study tests whether mild electrical stimulation of the vagus nerve (via the ear) can change how people learn from rewards and avoid threats. About 104 participants with high anxiety, high anhedonia, or both will play VR foraging tasks and brain-scan games. The goal is to und…
Sponsor: Dr. Nils B. Kroemer • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC