Melancholia

MONDO:0002444

A subtype of depression characterized by the inability to find pleasure in positive things combined with physical agitation, insomnia, or decreased appetite.

Also known as: depression with melancholic features, melancholic depression

56 clinical trials for this condition and its sub-types, 3 tagged with Melancholia itself.

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Where it sits in the disease tree

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↑ Depressive disorder (2382)

Including sub-types (56) Tagged with Melancholia (3)

Trials to join now! 2 Completed 1

Tailored magnetic pulses aim to restore pleasure in depressed patients

Symptom relief Completed

This study tested a personalized form of brain stimulation for people with depression who no longer feel pleasure (anhedonia). Sixty adults received either individualized, standard, or fake magnetic pulses to the brain over one week. The goal was to see if tailoring the stimulati…

Sponsor: University of California, San Diego • Aim: Symptom relief

Last updated Jun 27, 2026 09:05 UTC

Melancholia

Where it sits in the disease tree

Tailored magnetic pulses aim to restore pleasure in depressed patients