MALT lymphoma
MONDO:0007650An indolent, extranodal type of non-Hodgkin lymphoma composed of small B-lymphocytes (centrocyte-like cells). The gastrointestinal tract is the most common site of involvement. Other common sites of involvement include lung, head and neck, ocular adnexae, skin, thyroid, and breast. Gastric involvement is associated with the presence of H. pylori infection. (WHO, 2001)
Also known as: Extranodal marginal zone B-cell lymphoma, Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma), Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, Immunocytoma, MALT lymphoma, MALT-lymphoma, MALToma
2025 clinical trials for this condition and its sub-types, 30 tagged with MALT lymphoma itself.
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Sub-types of MALT lymphoma
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Tonsillar lymphoma 0 trials
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Could a lower dose of radiation plus a targeted pill treat this lymphoma just as well?
Disease control Not yet recruitingThis study is for people with a slow-growing type of lymphoma called MALT lymphoma that has not spread. It compares a very low dose of radiation (4 Gy) combined with the targeted drug orelabrutinib against the standard higher dose of radiation (24 Gy). The goal is to see if the g…
Phase 2 • Sponsor: Ruijin Hospital • Aim: Disease control
Last updated Jul 17, 2026 00:00 UTC
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New hope for tough lymphoma: Three-Drug showdown begins
Disease control Not yet recruitingThis phase II trial tests whether a drug called mosunetuzumab works better alone or combined with either zanubrutinib or polatuzumab vedotin for people with marginal zone lymphoma that has returned or stopped responding to treatment. The study will enroll 138 participants and mea…
Phase 2 • Sponsor: SWOG Cancer Research Network • Aim: Disease control
Last updated Jul 15, 2026 00:00 UTC
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AI helps target stomach cancer with less harm to healthy organs
Disease control Not yet recruitingThis study tests a new way to deliver radiation for gastric MALT lymphoma. Using AI, the treatment adapts each session to better protect nearby organs. About 25 adults with early-stage disease will take part. The goal is to see if this approach is safe and effective.
Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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New drug duo targets hard-to-treat lymphoma
Disease control Not yet recruitingThis study tests a combination of two drugs, nemtabrutinib and rituximab, in about 35 adults with marginal zone lymphoma, a slow-growing blood cancer. The goal is to see if the combo is safe and can shrink or eliminate tumors. Participants will receive the drugs by mouth and thro…
Phase 2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Scientists create atlas of rare lymphoma to unlock new treatment clues
Knowledge-focused Not yet recruitingThis observational study will analyze tissue samples from 400 people with MALT lymphoma, a slow-growing cancer. Researchers aim to build a comprehensive molecular and cellular map of the disease across different body sites. The goal is to identify tumor subtypes and biomarkers th…
Sponsor: International Extranodal Lymphoma Study Group (IELSG) • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC