Machado-Joseph disease
MONDO:0007182Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease, is the most common subtype of type 1 autosomal dominant cerebellar ataxia (ADCA type 1), a neurodegenerative disorder, and is characterized by ataxia, external progressive ophthalmoplegia, and other neurological manifestations.
Also known as: Azorean disease of the nervous system, MJD, Machado disease, Machado-Joseph disease, Nigro-spino-dentatal degeneration with nuclear ophthalmoplegia, SCA3, autosomal dominant striatonigral degeneration, spinocerebellar ataxia 3
30 clinical trials for this condition and its sub-types, 11 tagged with Machado-Joseph disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Machado-Joseph disease
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Machado-Joseph disease type 3 2 trials
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Machado-Joseph disease type 1 0 trials
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Machado-Joseph disease type 2 0 trials
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Machado-Joseph disease type 4 0 trials
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Can targeted brain zaps ease movement problems in a rare ataxia?
Disease control Not yet recruitingThis trial tests a non-invasive brain stimulation technique called transcranial temporal interference stimulation (tTIS) in people with spinocerebellar ataxia type 3, a genetic condition that affects coordination and balance. The stimulation targets a deep brain region involved i…
Sponsor: First Affiliated Hospital of Fujian Medical University • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Can brain stimulation tame ataxia?
Disease control Not yet recruitingThis trial tests whether deep brain stimulation (DBS) targeting the cerebellum is safe and feasible for people with spinocerebellar ataxia types 1 and 3, a group of inherited disorders that cause progressive problems with movement and coordination. The study will enroll 12 adults…
Sponsor: Gordon H. Baltuch • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Could stem cells help people with spinocerebellar ataxia? new trial aims to find out
Disease control Not yet recruitingThis Phase 2 trial tests whether umbilical cord stem cells can safely improve movement and coordination in people with spinocerebellar ataxia (types 1, 2, 3, and 6). Forty-five participants will receive the cells through an IV and a spinal injection. The main goal is to see if sy…
Phase 2 • Sponsor: Sclnow Biotechnology Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC