Lynch syndrome 2
MONDO:0012249An autosomal dominant hereditary neoplastic syndrome caused by pathogenic variants in the MLH1 mismatch repair gene. It is characterized by an increased risk of colorectal cancer in the absence of extensive polyposis, endometrial, ovarian, gastric, small intestinal, and urinary tract cancers, often occurring at younger ages.
Also known as: Hereditary non-polyposis colon cancer type 2, Hereditary nonpolyposis colorectal cancer type 2, Lynch 2 syndrome, MLH1-related Lynch syndrome, colorectal cancer, hereditary nonpolyposis, type 2, familial non-polyposis colon cancer type 2, COCA2, HNPCC2
2900 clinical trials for this condition and its sub-types, 3 tagged with Lynch syndrome 2 itself.
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Blood test could spot colon cancer before it spreads
Diagnosis Recruiting nowThis study is testing a blood test (called a liquid biopsy) to see if it can find colorectal cancer, pre-cancerous growths (adenomas), and cancers linked to Lynch syndrome at an early stage. Researchers will enroll 1,200 people who have already had a colonoscopy. The goal is to s…
Sponsor: San Raffaele University • Aim: Diagnosis
Last updated Jun 27, 2026 09:11 UTC
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New study aims to unlock why lynch syndrome patients still get cancer despite surveillance
Knowledge-focused Recruiting nowThis study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find cl…
Sponsor: San Raffaele University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Pill cameras could spot rare gut cancers in lynch syndrome patients
Knowledge-focused Recruiting nowThis study is testing whether a swallowed video capsule (a pill-sized camera) can help find small bowel cancer early in people with Lynch syndrome, a genetic condition that raises cancer risk. About 100 participants will swallow a capsule every two years to take pictures of their…
Sponsor: San Raffaele University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC